- The East Hall, the oldest building, houses the Division of Advancement and Development. Initial work on the building began in 1907 and was completed in 1909.
- The J. L. Moran Hall, completed in 1944, houses faculty offices and classrooms for the Department of History and Political Science and the Department of English and Foreign Languages. It also has an auditorium with a seating capacity of 500.
- The E. I. Cunningham Hall, completed in 1947 and renovated in 2012, houses the Center for Student Success, Office of Admissions, Financial Aid, Student Accounts, Career Connections Registrar’s Office, and Faculty Development.
- The Teachers’ Cottages, completed in 1947, currently house the Art Program, the Chaplain’s Office, the Literature Evangelist Training Center, New Beginnings, Public Safety and USM offices.
- The W. H. Green Hall, completed in 1952, houses faculty offices and classrooms for the Departments of Psychological Sciences and Social Work.
- The H. E. Ford Hall, completed in 1954 and renovated in 2014-2015, houses Communication Department offices. Adjacent to Ford Hall, the Leroy and Lois Peters Media Center houses Oakwood University Broadcast Network (OUBN), studios, offices, and editing suites.
- The F. L. Peterson Hall, completed in 1955.
- The N. E. Ashby Auditorium, constructed in 1956, is the gymnasium.
- The Oakwood Market and Bookstore building was completed in 1957.
- The Physical Plant building was completed in 1959 and also houses the Mailroom.
- The Anna Knight Hall, completed in 1960 and renovated in 1992, houses the Department of Education.
- The G. E. Peters Hall, completed in 1964, houses faculty offices, classrooms and the fine arts auditorium for the Department of Music.
- The Bessie Carter Hall, completed in 1966 and renovated in 2014-2015, is the residence hall for freshman women.
- The W. J. Blake Memorial Center, completed in 1968 and renovated in 2008 and 2009, contains the administrative offices of the university, student dining hall, meeting rooms and the presidential dining suite.
- The O. B. Edwards Hall, completed in 1969, is the residence hall for upper-class men.
- The Eva B. Dykes Library, completed in 1973, is the university's learning, resource, and research center. It is also home to the University Archives, Clara Peterson Rock Museum, a computer laboratory, the Ellen G. White Research Center, the Anna Knight Women’s Leadership Center, the Copy Express, group study rooms, conference rooms and classrooms.
- The J. T. Stafford Building, completed in 1974, is an educational center consisting of class
- rooms, laboratories, and offices.
- The W. R. Beach Natatorium, completed in 1974, houses an Olympic-size swimming pool, classrooms, and offices for the Department of Health and Human Sciences.
- The Oakwood University Church, completed in 1977, has a seating capacity of 2,700.
- The Moseley Complex, completed in 1977 and renovated in 2007, houses faculty offices and classrooms for the Department of Religion and Theology, and the C. T. Richards Chapel.
- The E. A. Cooper Science Complex, completed in 1981, houses laboratories, classrooms, offices, and storage space for the Departments of Biological Sciences, Chemistry, Health and Human Sciences, Nutrition and Dietetics, Mathematics and Computer Science, Nursing and the Child Development Lab.
- The Natelka E. Burrell Hall, renovated in 1982, houses offices and classrooms for the Department of Communication.
- The Millet Activity Center (formerly Oakwood University Skating Rink) was completed in 1986 and renovated in 2010. It houses Student Activities offices, a TV room, and a game room, in addition to the skate floor and adjoining racquetball courts.
- The Trula E. Wade Residence Hall, completed in 1991, is the residence hall for upper-class women.
- The Business and Technology Complex, completed in 2001, houses faculty offices and classrooms for the Business and Information Systems and Adult and Continuing Education Departments, four computer labs, an auditorium that seats more than 300 people, a Board of Trustees meeting room, and a faculty resource area and the offices of Oakwood University Information Technology Department (OUIT) The facility is fully networked and Internet and audiovisual ready.
- The West Oaks Apartments, completed in 2002, consists of six two-story apartment buildings, three for male residents and three for female residents. The West Oaks Clubhouse was completed in 2004 and features ground floor and basement lounges, a kitchen, laundry facilities and administrative offices.
- The Morningstar House, donated by the Harris Home Foundation, was relocated to campus and restored in 2002 by the Alumni Association.
- The Oakwood University Industries (OUI) building, located at 4920 University Square on the southernmost part of the campus, was acquired in 2003. It houses institutional suppovices such as the WJOU Radio Station and the office of the Oakwood Memorial Gardens manager. It also houses businesses that network with and/or employ Oakwood students and employees. Contact information for the OUI facility is available through the Division of Advancement and Development.
- The Bradford-Cleveland-Brooks Leadership Center (BCBLC), a 10,000 square foot extension to the Calvin E. Moseley Religion Complex completed in 2007, houses the Leadership Center for continuing education in ministry and the Center for Adventist-Muslim Relations. The extension includes an auditorium, four classrooms, a learning research lab, and four offices.
- The Holland Hall, a 256-bed facility completed in 2008, is the residence hall for freshman and sophomore males. It provides multiple amenities including: suite-style living, complete with kitchenettes; single/double-occupancy bedrooms with wireless and cable television access; study rooms; laundry facilities on each floor; a multipurpose worship room; and an activity center with exercise, game and entertainment areas.